The central focus of our research laboratory lies at the dynamic intersection of Development and Stem Cell Biology, tissue engineering, pathophysiological studies, drug screening, and the potential for revolutionary cell replacement therapies for disease management and cure. Our overarching mission is to leverage the unprecedented capabilities of Human Stem Cell-derived 3D organoids to emulate the intricate cellular interactions and developmental pathways observed in living organisms. By doing so, we aim to unravel the complexities underlying organ development, differentiation, and maturation, while simultaneously bridging the gap between scientific inquiry and clinical applications for Cardiovasular and Metabolic Health.
Welcome to a realm of transformative scientific exploration, where we are charting bold pathways to illuminate a radiant future for unmet clinical needs in cardiometabolic health. Central to our pioneering spirit is the revolutionary concept of human pluripotent stem cell-derived 3D organoids. Within these extraordinary three-dimensional constructs lie the seeds of possibility — a canvas for disease modelling, a stage for drug discovery, and a platform for exploring the uncharted territories of potential cell replacement therapies. With unwavering dedication, we recreate the symphony of microenvironments and developmental pathways that guide the emergence of organs, gifting us with unprecedented insights into the mechanics of disease and novel avenues of treatment.
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In this episode, Reena Singh joins us to discuss her research and one of her recent publications titled, Enhanced Structure and Function of Stem Cell-Derived Beta-Like Cells Cultured on Extracellular Matrix.
Did you miss Dr Reena Singh's webinar regarding Stem Cell Therapy for Type 1 diabetes: Progress, Challenges and Future Directions ?
A recent STEM CELLS Translational Medicine article from the lab of Reena Singh (University of Sydney, NSW, Australia) reports on how the culture of human pluripotent stem cell (hPSC)-derived beta cells on basement membrane proteins enforces structural polarity...